Wednesday, August 26, 2020

Week 3 540 Essay Example | Topics and Well Written Essays - 750 words

Week 3 540 - Essay Example Enter the Wireless Communication market,† (Simulation). An examination done on the possibilities of these two proposition, uncovers that the plan or proposition to grow the current Digital Imaging or Dig-Image piece of the pie, can be useful than the alternative of entering the Wireless Communication or W-Comm. Be that as it may, simultaneously, this choice to go for Dig-Image has certain inside just as outer hazard. Along these lines, this paper will break down the dangers of this venture choices and critically the alleviation of those dangers. Regularly, associations needing to expand its worth, as to put resources into ventures that gives a positive Net Present Value. The Net Present Value of a speculation venture is normally controlled by the deduction of the undertakings all out expense from the current estimation of the activities expected future incomes. What's more, in the event that the Net Present Value is higher than the tasks cost, at that point it is normal that the undertaking will expand the organizations esteem According to the layout gave by the Marketing Research Reports, SAI should utilize the best capital planning approach as NPV, as it will distinguish incomes as opposed to benefits. At that point, it uses all the incomes and thus limits the incomes appropriately. Along these lines, on account of Dig-Image, the deals of it in new markets rely on its current piece of the pie from the worldwide point of view, cost per item and critically the size of market. As SAI through its Dig-picture proposition attempts to extend its piece of the overall industry all through the world, it ought to know about the dangers related with outside trade introduction and the important moderation methodology of supporting. Outside presentation in the sense, the successive vacillations in the trade rates will adversely influence the working incomes and critically the dollar estimation of the SAI’s complete resources and liabilities. This hazard will have both present moment just as long haul impact and could gouge any new activities from SAI. This

Saturday, August 22, 2020

Poverty and Animal Welfare free essay sample

As the world continues creating, numerous things happen like ecological issues, destitution, and creature government assistance. We can't preclude that the results from claiming those issues experience made numerous difficulties our life. Therefore, youngsters these days are considerably more mindful and worried about those issues than past age. In the first place, ecological annihilation is one of the most noteworthy overall issues. The water is contaminated, the air is dirtied, and the normal assets decline a lot.At the present, individuals start to know about rare assets while previously, it was anything but something essential and individuals wasted each one of those valuable bounties. These issues will influence people’s life colossally. In this manner, various ecological developments are sorted out by youth thinking about preservation of normal assets and territories, an Earth-wide temperature boost, ozone consumption and a lot of different issues, albeit past ages took care about totally in any case concerns. Besides, because of the advancement of the Internet and media, youngsters find out about the present circumstance of the world and are given loads of data about these issues. We will compose a custom article test on Destitution and Animal Welfare or on the other hand any comparative point explicitly for you Don't WasteYour Time Recruit WRITER Just 13.90/page As the mindfulness at that point will be spread around on the Internet, an ever increasing number of individuals will see progressively about the issue and begin to do the same number of things as they can to keep these issues from developing. We can say that the Internet and media assumes a major job in making youths mindful of these sort of things.Poverty and creature government assistance are likewise issues that individuals ought to extraordinarily think about. Ordinary while numerous individuals can unreservedly make the most of their feast following a dedicated day others can't. These individuals don't have a spot to rest, a home to remain and they need to battle each and every day. Also, as today government arranges progressively valuable exercises for youngsters, adolescents can see obviously that there are as yet numerous individuals who can't have an actual existence as they do. From that point forward, they will get things done to have destitute individuals and make chances for them to discover a job.Young people are additionally worried about creature government assistance, ensuring creature morals and rights. For example, a lot of youthful people help in discovering home for lost canines, felines and different pets. Some volunteer to take care of pets while others attempt to discover individuals who need to raise a pet. Taking everything into account, as the world changes, the individuals likewise change the manner in which they live and begin to know about new things happening ordinary. That is the reason young people are more in contact with these issues than past ages.

Friday, August 21, 2020

Before After You Apply EA - UGA Undergraduate Admissions

Before After You Apply EA - UGA Undergraduate Admissions Before After You Apply EA With the Early Action deadline approaching, here are a few more detailed steps to take both before and after you apply. BEFORE Get a copy of your SSN card to make sure your information is correct for both admissions and Financial Aid data. Print out a copy of your official HS transcript to help with the self-reported grades section. Update and print out a copy of your résumé for the activities/sports/volunteer/work/etc. sections. Get your payment information, and know that we can only accept credit card payments from 7 a.m. until 11:00 p.m. Send in your SAT/ACT scores to UGA, and remember that we superscore and only use your highest scores, so there is no need to wait until after you apply or after you see the scores to send them. You can send updated test scores after you apply, but we suggest sending in any scores you have already received. Do not be late submitting your application, as we shut off the Early Action deadline after 10/15, and we cannot reopen it. Make sure you both complete the application and select a payment option, as both are required to apply. Do not wait until the night of the deadline to apply, as that is when your computer will decide to freeze up. AFTER Be patient as we load your application into our our system and match up test scores and supporting documents. Test scores are loaded on Tuesdays and Fridays, and are not always sent immediately by the testing agency. We suggest giving our office 5-10 business days to match up items, so you not need to send items multiple times. Documents (transcripts, counselor/school evaluations, etc.) that are sent prior to applying take a little while longer than items sent after applying, so we suggest sending in materials after you apply. We accept electronic documents such as GACollege411 transcripts, Parchment (an electronic document system) documents and our own counselor form, as these get to us much quicker than printed documents that are mailed. We are fine with mailed documents, but it takes more time to get to us through the mail, opened, scanned and into a file than with electronic documents. We will accept all SAT/ACT scores that are both taken and sent by the 10/15 deadline, so we are fine with the October SAT but we cannot accept the October ACT. As well, in order for us to use your ACT scores, we need at least one ACT Writing score. Make sure you send us scores on time so we can review your file. A day or so after you apply, we will load your application into our system. You will then be able to log into the myStatus page. This is where you will be able to enter your counselors email for the school/counselor evaluation. We are okay if your counselor chooses to send in a counselor form through Parchment instead. Use the myStatus page to keep track of your application and supporting documents/test scores. You (the applicant) are ultimately responsible for your application, but we will send some reminder emails/texts if your file is incomplete. I repeat, use the myStatus page to keep track of your application. Remember, we need an application fee, an official transcript, a school/counselor evaluation and an SAT or ACT (with Writing) score to complete your file, and the supplemental items EA submission deadline is 10/22. We cannot review your application without all these items. I hope this helps, and Go Dawgs!

Sunday, May 24, 2020

How Far Did Napoleon Maintain the Aims of the French...

Liberty, property, equality, fraternity, uniformity, utility, popular sovereignty; these are just some words that best describe the aims and principles of the French Revolution. Did Napoleon Bonaparte I, Emperor of France, hinder, maintain, or in fact ‘further’ the aims of the revolution?, this is a question in which many historians argue about and can come to no definitive answer. First of all, in an economic sense, Napoleon definitely followed some of the earlier revolutionary principles in his reform of the nation. Napoleon introduced limits on grain exports (due to poor harvests) in 1811 and placed price limits on bread and grain in 1812, much like the revolutionary governments such as ‘The Assembly’ and ‘The Convention’. Napoleon†¦show more content†¦For example; he established the Legion of Honour to reward loyalty and was open to all who served the state, as well as honours for other members of society. However, as it turned out the majority of the recipients were of ‘noble birth’ and most received these honours for remaining loyal and honest to Napoleon. Although Napoleon talked about equal opportunities, the rich and wealthy could abuse their rights. Notables could, for instance, buy hereditary rights and rich men could avoid conscription by paying a poorer substitute to serve. Opportunities were in fact very limited for improving status lower down the social hierarchy and entry to government posts was largely dependent on income. In this sense, Napoleon ‘talked up’ the rights to equal opportunities in France, although there were more (equal rights) than under the Ancien Rà ©gime. In terms of Politics and how France changed politically, Napoleon managed to maintain the aims of the French Revolution, as well as abuse them some of the time. The creation of the Napoleonic code (Civil Code) of 1804, in which Napoleon took a great interest in, created a law for the whole of France that incorporated the aims and principles of the French Revolution. Uniformity was achieved as Napoleon was able to combine all the overlapping systems of law into one. This code brought equality before the law and included; the abolition of feudal dues and serfdom whereShow MoreRelatedContemporary Issues in Management Accounting211377 Words   |  846 Pagesoriginal analyses of the possibilities for meaningful accounting standardization. With an agenda as rich as this, it is all the more praiseworthy that Michael maintained his dialogues with both the academic and the practitioner communities. But that he did. Those who know Michael Bromwich are not surprised by his many involvements, h owever. Constantly striving, always curious and ever personable, he has developed a pattern of interests, involvements, and friendships that have sustained his very effective

Thursday, May 14, 2020

The Quotation Of Maya Angelou - 1066 Words

1. Quotation and page number: â€Å"If growing up is painful for the Southern Black girl, being aware of her displacement is the rust on the razor that threatens the throat† (Angelou 4) Speaker: Maya Angelou Significance: Maya was supposed to give her Easter speech in a beautiful dress she imagined would make her look like a white movie star. Instead, it was an ugly hand me down and too long for Maya’s liking. Maya was disappointed in her dress because not only was it not what she expected, but she realized she will never look or be treated like a white movie star. The quotation shows that Maya Angelou was aware of the difficulties of African Americans at such a small age. Maya acknowledges the fact that she won’t be treated the same as†¦show more content†¦This quote is important because based on stereotypes developed by other people, black people are violent and rude. Maya would likely have been punished for standing up for her grandmother while the white girls would be sympathized for harassing an elderly woman. Part II Pages 97-192 4. Quotation and page number: â€Å"Words mean more than what is set on paper. It takes the human voice to infuse them with the shades of deeper meaning.† (Angelou 98) Speaker: Mrs. Flowers Significance: Mrs. Flowers connects with Maya trying to get her to talk again. Mrs. Flowers accomplishes her goal by first saying this quote, which gave Maya something to think about. This quote is significant because Mrs. Flowers helped influence Maya to talk again and it was okay to talk and express how she feels and that words were more important said aloud than on paper. Although, both had importance and meaning 5. Quotation and page number: â€Å"It was brutal to be young and already trained to sit quietly and listen to charges brought against my color with no chance of defense.† (Angelou 180) Speaker: Maya Angelou Significance: Maya and the rest of her graduating class are at graduation hoping it will be full of joy and happiness. Instead, they were reminded of how they were â€Å"not capable† to be anything but housewives or basketball players. This quote is significant because it shows howShow MoreRelatedUnfair Ism Or Racism?946 Words   |  4 Pagespresent in the united states since the colonial era or rather said the slave era. In another words African-American at that time were treated unfairly because at that time they were not valuable as a human beings. In the essay ‘’Graduation’’ by Maya Angelou and ‘’Notes of a native son’’ by James Baldwin, One can see how racism and unfairness were present in the society at that time. In ‘’Notes of a native son’’ by James baldwin starts off by saying how his father’s funeral was on his 19th birthdayRead MoreThe Importance of Determination Essay687 Words   |  3 Pagesthe obstacles that stand in their way. â€Å"Mother to Son† by Langston Hughes and â€Å"Still I Rise† by Maya Angelou are two different works written by two different authors yet they both convey the same message. Together, the two authors stress the significance of pushing harder when faced with conflicts rather than simply giving up. Using figurative language and repetition, Langston Hughes and Maya Angelou effectively emphasize this message in both of their poems. In both poems, both authors attemptRead MoreEssay on Maya Angelou’s â€Å"Champion of the World†859 Words   |  4 PagesAssignment #1: Maya Angelou’s â€Å"Champion of the World† Questions on Meaning 1. What do you take to be the author’s Purpose in telling this story? I think the author’s purpose of writing this story was to tell about how she felt that Joe Louis was more then just a boxer. Joe was a hero to the African American community. She tells about how important it was for Joe to win the fight and what the outcomes could be if he did not win. 2. What connection does Angelou make between the outcomeRead MoreA Homemade Education By Malcolm X And Letter From Birmingham Jail By Martin Luther King Jr.1796 Words   |  8 Pagesdampened by the discouragement that must inevitably come.† This theme of perseverance and persistence is exemplified through the works of Malcolm X, Martin Luther King Jr. and Maya Angelou who are defying social norms by revolting against racial injustice and educational inequality. Based on the texts, â€Å"Graduation† by Maya Angelou, â€Å"A Homemade Education† by Malcolm X and â€Å"Letter from Birmingham Jail† by Martin Luther King Jr., it is clear that the writers/ narrators show a great deal of persistence.Read MoreCompare and Contrast Essay866 Words   |  4 Pagesable to do this- each in their own way. The first difference between Fish Cheeks and Caged Birds is the format of the literature. Amy Tan in Fish Cheeks chose to write a short descriptive essay (Tan, 2013). While Maya Angelou wrote in Caged Bird, a narrative in a poem format (Angelou, 1983). Each individual artist had a certain way in which, they wanted to express a significant event that they have learned throughout their life. I felt that it was easier to relate to Amy Tans message because sheRead MoreI Know Why The Caged Bird Sings1477 Words   |  6 Pages*Note: The narrator is referred to as Marguerite in the questions that deal with her memoirs, since that is how she refers to herself throughout the book. In instances where the author is sharing her beliefs and philosophy, she is referred to as Maya Angelou. Chapters 18-21 What is the author s theory about peoples belief in divine intervention? The author’s theory about the peoples’ belief in divine intervention is that the poorest existence is attributed to God’s will, but as their materilisticRead MoreTwo Pesentations of Love in Maya Angelous Poems: ‘A Kind of Love, Some Say’ and ‘Where We Belong, A Duet’1008 Words   |  5 PagesThese poems written by Maya Angelou both portray love in a very different way. The detrimental effects of love are shown in ‘A Kind of Love, Some Say’ and the empowering effects of love are shown in ‘Where We Belong, A Duet’. ‘A Kind of Love, Some Say’ shows that Love and relationships is what causes the struggle for identity as in the other poem being in love and in a relationship allows the persona to find their true identity. The poem ‘A kind of love some say’ is one of Mayas more emotionalRead MoreEssay on I Know Why the Caged Bird Sings by Maya Angelou2409 Words   |  10 Pagesskin. Since they were evidently treated differently, many despised the fact that they were black. As a result of their helpless circumstances, it was understandable that many blacks during that time lacked confidence and self-acceptance. Maya Angelou was an African American girl who grew up during this challenging time. During her childhood, she witnessed and experienced racial prejudice first hand. She had difficultly understanding and accepting the consequences that accompanied belongingRead MoreReview Of I Know Why The Caged Bird Sings 1553 Words   |  7 Pagesnovel â€Å"I Know Why The Caged Bird Sings† by: Maya Angelou, she illustrates Marguerite combating society from a disadvantaged position. Set in the United States during the time of racism and segregation towards the black community, the novel displays the contrast in Maya’s upbringing in Stamps, St. Louis to San Francisco and her constantly changing development and maturity in herself through her effectiveness to conquer difficult situations. Maya Angelou uses symbolism in the form of the caged birdRead MoreEssay On Maya Angelou1879 Words   |  8 PagesMaya Angelou is one of the most important American Authors who ever lived. She was an African-American woman who spoke her mind and when someone told her she couldn’t do something, it made her want to do it even more so that she could prove them wrong (Shapiro). Her life was incredibly difficult, but it made her who she was and influenced her writing and poetry immensely. As Gary Younge once said, â€Å"To know her life story is to simultaneously wonder what on earth you have been doing with your

Wednesday, May 6, 2020

Implementation of E-Commerce on Supply Chain Management

SCHOOL OF COMMERCE D.A.V.V MAJOR RESEARCH PROJECT ON â€Å"Implementation of e-commerce on supply chain management with reference to logistic management† A Research Dissertation Submitted for Partial Fulfillment of Degree of Bachelor’s of Foreign Trade (2009-2012) GUIDED BY: SUBMITTED BY: Mr. Vandit Hedau Rohit Wagle MBA FT(5 yrs) 6th Sem Preface A supply chain is a system of†¦show more content†¦LITERATURE REVIEW 24 CHAPTER 3.RESEARCH METHODOLOGY 27 3.1THE STUDY 3.2THE DESIGN 3.3THE TOOLS OF DATA COLLECTION CHAPTER 4. METHODOLOGY CASE STUDY 4.1 ACE PVT. LTD. 33 4.2 FAABER PAINTS PVT. LTD. 37 4.3 Hydrocontrol Pvt. Ltd. 39 4.4 Sejal Glass Pvt. Ltd. 41 CHAPTER 5. RESULT 44 CHAPTER 6.SUGGESTION AND CONCULSION 46 Reference 1.INTRODUCTION 1.1 Supply Chain Management:- A supply chain is a system of organizations, people, technology, activities, information and resources involved in moving a product or service from supplier to customer. Supply chain activities transform natural resources, raw materials and components into a finished product that is delivered to the end customer. In sophisticated supply chain systems, used products may re-enter the supply chain at any point whereShow MoreRelatedImpact Of E Commerce On Global Economy1352 Words   |  6 PagesIntroduction Impact of E-Commerce on Global Economy It is exciting area especially E-Commerce. The advancement in World Wide Web, computers and mobile wireless communication technologies are transforming the way business is conducted. The success stories of Amazon, eBay are few examples. New technologies have provided the required platform for innovation, growth, shopping convenience, and price advantage due to the boundary less competition. Business leaders across the industry are developingRead MoreChap12 Ais1343 Words   |  6 PagesChapter 12 test bank TRUE OR FALSE. 1. Private industrial networks are the largest form of B2B e-commerce. ANS. TRUE 2. EDI systems are seller-side solutions. ANS. FALSE 3. Net market places are growing at a faster rate than private industrial networks. ANS. TRUE 4. E-distributors typically operate in vertical markets. ANS. FALSE 5. Exchanges tend to be biased toward the seller even though they are independently owned and presumably neutral. ANS. FALSE 6. Industry consortia are typicallyRead MoreExam Summary949 Words   |  4 Pagesacquisition of goods and services) 3.) Explain the challenges in implementation of enterprise system and the impacts on organisation 4.) Describe the selection, acquisition and implementation of ES ERP – Enterprise Resource planning systems integrate internal and external management information across the entire organisation , embracing finance, manufacturing, sales and service, customer relationship management, Software and Vendor selection Key words * ERP purchase process Read MoreE-Commerce Strategies for a Local Independently Owned and Operated Restaurant792 Words   |  3 Pagese-Commerce Strategies for a Local Independently Owned and Operated Restaurant What Internet business model would be appropriate for the company to follow in creating a Web site and why? The best possible Internet business model for the local restaurant Kenos would be multichannel retailing and new customer acquisition through event marketing, couponing and pervasive use of social media to promote special events. Kenos is a family-run small restaurant that also has a small sports bar attachedRead MoreGeneral Motors E Procurement906 Words   |  4 PagesREPORT ON E-PROCUREMENT Case on General Motors †¢ What business is the organization in? General Motors, as a representative U.S.–based automobile manufacturer, has several characteristics that make it a perfect fit for e-procurement and a great example of how e-procurement is reshaping U.S. Manufacturing. First, GM is the major part of a large supply chain. The scope of this supply chain and the role of GM in it is reflected in its annual $63 billion procurement expense. The costRead MoreErp Helps Productivity at Northern Digital Inc767 Words   |  4 PagesIdentify the supply chain segments that the ERP supports, be specific. 3. Relate this case to Porters value chain and to its competitive model (Chapter 14). Show the ERPs contribution. 4. Enter intuitivemfg.com and report on the capabilities of their ERP product. 5. Relate this case to business planning and strategy. Answer for Question 1 ERP covers the overall processes of the whole organization from front-office to back-office operations. It supports internal supply chain within an enterpriseRead MoreCase Study : Supply Chain Management Essay2039 Words   |  9 PagesIntroduction â€Å"The best supply chains aren’t just fast and cost-effective. They are also agile and adaptable, and they ensure that all their companies’ interests stay aligned.† (Lee, 2004) Supply chain management or SCM is a series of interconnected and interdependent operational functions and decisions. It is the blend of art and science that goes into enhancing the company’s procedures in obtaining the raw materials it requires to create a product or service and distribute it to customers (HarlandRead MoreE Commerce : A Type Of Business1328 Words   |  6 PagesE-COMMERCE INTRODUCTION: Electronic Commerce, usually addressed as E-commerce can be described as a type of business used for commercial transactions which involves transfer of information across the internet. It helps people in electronically exchanging goods and services with ease as there is no time or distance barrier. Types of E-commerce: (i) Business to Business (B2B): Firms directly deal with each other, (i.e.,) manufactures sell their goods to Distributers. Here, the pricing will varyRead MoreE Commerce Of Goods, Services Or Information Between Different Companies1086 Words   |  5 Pages2.2 B2B- and B2C-Business B2B also covers e-commerce of goods, services or information between different companies. Therefore, the Business to Business Marketing a very large part of e-business. Commodity exchanges or wholesale deals can be referred to on the Internet as B2B platforms. In addition to trade in goods and their logistics, warehousing and distribution are also part of this business. Overall, these business relations can be held between manufacturers, suppliers, logistics and distributionRead MoreThe Problem Of Supply Chain Management Research1448 Words   |  6 Pagesaddresses an issue within supply chain management research that has not been given much attention, and thereby attempts to bring focus to modern slavery within organizations with international supply chains. It calls for new theory development towards the detection and elimination of slavery within global supply chain, as well as the development of new tools and indicators that can be used to detect slavery within supply chains. Aft er detecting slavery within a supply chain, complete withdrawal of

Tuesday, May 5, 2020

The play Hamlet, by William Shakespeare Essay Example For Students

The play Hamlet, by William Shakespeare Essay The play Hamlet, by William Shakespeare, was written in the early 17th century, during the Elizabethan era. In this time period, women were expected to marry at a young age and have children to carry on the family name; this was to be their only role in life. Women were not believed to be rational and intelligent human beings. For centuries, women have been imprisoned within this box, constricted and restrained by the male view of what womens role in life is. They are mothers, daughters, girlfriends, and wives but never philosophers, business people, investors, owners, doctors or lawyers; they were thought to not be capable in such occupations. In Hamlet, Shakespeare uses this age-old idea and because of that the role of women is minimized to that of a mother, daughter, and wife. However, Shakespeare does cast a very sexual light on the role of women within this play. The female characters within the play Hamlet play a very minimal role and only serve to further develop the characters of the men within the play. Gertrude is both a mother and a wife within this play and she helps to motivate Hamlet further in gaining his revenge on Claudius. Hamlet states: And yet, within a month à ¢Ã¢â€š ¬Ã¢â‚¬Å" / Let me not think on it à ¢Ã¢â€š ¬Ã¢â‚¬Å" Frailty, thy name is woman à ¢Ã¢â€š ¬Ã¢â‚¬Å" / A little month, or ere those shoes were old/ With which she followed my poor fathers body, / Like Niobe, all tears à ¢Ã¢â€š ¬Ã¢â‚¬Å" why she, even she à ¢Ã¢â€š ¬Ã¢â‚¬Å" / à ¢Ã¢â€š ¬Ã‚ ¦ Would have mourned longer à ¢Ã¢â€š ¬Ã¢â‚¬Å" married with my uncle, / à ¢Ã¢â€š ¬Ã‚ ¦ Within a month, / Ere yet the salt of most unrighteous tears / Had left the flushing in her galled eyes, / She married. I.ii.ll 147-158. Hamlet speaks of Gertrudes sudden marriage to Claudius after the death of Old Hamlet. In the second line of the above quote, Hamlet uses the world frail to describe women, meaning that women are weak and not in control of their emotions. Shakespeare also does nothing to develop Gertrudes character any further; we learn very little about her thoughts and feelings towards Old Hamlet, her marriage to his brother, and even Claudius himself. Ophelia also serves to motivate Laertes to further his revenge against Hamlet. By heaven, thy madness shall be paid by weight/ Till our scale turn the beam IV.v.ll 167-168. Yet, neither of these women were the original motivation; they only served to further motivate both Hamlet and Laertes. Both Ophelia and Gertrude are portrayed as weak females with virtually no independence. An example of this is Ophelia obeying her father when he commands her to stop seeing Hamlet. I shall obey, my lord I.i.ll 141. As a daughter, she immediately surrenders to her father and brothers will. Ophelia is further characterized as weak when she goes insane. When compared to Hamlet, we see that Hamlet managed to overcome his fathers death and plot revenge on his fathers murderer. Ophelia, on the  other hand, succumbs to the distress and shock and goes insane instead. This is saying that men are strong and dont let their emotions overcome them, unlike women. Even Gertrude moves instinctively towards the safer choices given to her. An example of this is when she seeks out Claudius right after her confrontation with Hamlet. Bestow this place on us a little while. Ah, my good lord, what have I seen to-night! IV.i.ll 4-5. She does not stop to even think about her situation or what has happened. Gertrude is completely reliant on the men in her life and only seems to be able to think for herself in social situations. .ubfa04828c6f5bce10e8a919758e9df1a , .ubfa04828c6f5bce10e8a919758e9df1a .postImageUrl , .ubfa04828c6f5bce10e8a919758e9df1a .centered-text-area { min-height: 80px; position: relative; } .ubfa04828c6f5bce10e8a919758e9df1a , .ubfa04828c6f5bce10e8a919758e9df1a:hover , .ubfa04828c6f5bce10e8a919758e9df1a:visited , .ubfa04828c6f5bce10e8a919758e9df1a:active { border:0!important; } .ubfa04828c6f5bce10e8a919758e9df1a .clearfix:after { content: ""; display: table; clear: both; } .ubfa04828c6f5bce10e8a919758e9df1a { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .ubfa04828c6f5bce10e8a919758e9df1a:active , .ubfa04828c6f5bce10e8a919758e9df1a:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .ubfa04828c6f5bce10e8a919758e9df1a .centered-text-area { width: 100%; position: relative ; } .ubfa04828c6f5bce10e8a919758e9df1a .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .ubfa04828c6f5bce10e8a919758e9df1a .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .ubfa04828c6f5bce10e8a919758e9df1a .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .ubfa04828c6f5bce10e8a919758e9df1a:hover .ctaButton { background-color: #34495E!important; } .ubfa04828c6f5bce10e8a919758e9df1a .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .ubfa04828c6f5bce10e8a919758e9df1a .ubfa04828c6f5bce10e8a919758e9df1a-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .ubfa04828c6f5bce10e8a919758e9df1a:after { content: ""; display: block; clear: both; } READ: The climatic scenes EssayGertrude states: Good gentlemen, he hath much talked of you, / And sure I am, two men there are not living / To whom he more adheres. If it will please you/ To show us so much gentry and good will/ As to expend your time with us awhile, / For the supply and profit of our hope, / Your visitation shall receive such thanks/ As fits a kings remembrance. II.ii.ll 19-26. Gertrude is in control of herself here and doesnt, at any point, look to Claudius for assistance as she normally does. The one time that Gertrude does try and show some independence is when she drinks from the poisoned cup. I will, my lord, I pray you, pardon me V.ii.ll 302. The message being given here is that without the guidance of men, women cannot function because if Gertrude had listened to Claudius, she would not have drank and survived. Throughout the entire play Hamlet, both Ophelia and Gertrude were controlled by the men in their lives; they are not in control of their surrounding at any time. Ophelias immediate obedience to Polonius when he orders to stop seeing Hamlet is an example of this. I would not, in plain terms, from this time forth, / Have you so slander any moment leisure, / As to give words or talk with the Lord Hamlet. / Look to it, I charge you. Come your ways I.iii.ll 137-140. Polonius tells Ophelia what she has to do and doesnt allow her to think for herself. Each action that is done by either woman is the result of an earlier action done by one of the male characters. Ophelia goes crazy and then dies because of Polonius death and Hamlets rejection of her. O, this is the poison of deep grief. It springs/ all from her fathers death IV.v.ll 74-75. Another example is when Polonius plans to use Ophelia as bait to figure out the cause of Hamlets madness; he is controlling what she does and says here. At such a time Ill loose my daughter to him, / Be you and I behind an arras then, / mark the encounter II.ii.ll 175-177. Ophelia, walk you here. à ¢Ã¢â€š ¬Ã¢â‚¬Å" Gracious, so please you, / Well bestow ourselves. à ¢Ã¢â€š ¬Ã¢â‚¬Å" / Read on this book, / That show of  such an exercise may colour/ Your loneliness III.i.ll 48-52. They are completely dominated by the male figures in their lives. The role of women in Hamlet is also very sexually oriented. There are many references to prostitutes, sexual favors, incest and sex itself. There are also many comparisons between objects and emotions to sexual objects or people. An example of this is when Claudius compares the guilt he is feeling to a prostitute. How smart a lash that speech doth give my conscience! / The harlots cheek, beautied with plastering art, / Is not more ugly to the thing that helps it/ Than is my deed to my most painted word III.i.ll 57-60. Each negative feeling or emotion, such as guilt, is compared to women, as if they are somehow similar. In Hamlets confrontation with Ophelia, he tells her many times to go to a brothel where she belongs, as she acts much like a whore does. Get thee to a nunnery. Why wouldst thou be a/ breeder of sinners? III.i.ll 131-132. Hamlet also speaks of womens attitude and how they pretend to be innocent and beautiful but are really not. Hamlet states: I have heard of your paintings too, well enough. / God hath given you one face, and you make yourselves/ another. You jig and amble, and you lisp, and nick-/ name Gods creatures, and make your wantonness/ your ignorance. Go to, Ill no more on it. It hath made/ me mad. I say, we will have no more marriages. Those/ that are married already, all but one, shall live. The rest/ shall keep as they are. To a nunnery, go. .ud6d64ed4f6c7d79446aade3da5034571 , .ud6d64ed4f6c7d79446aade3da5034571 .postImageUrl , .ud6d64ed4f6c7d79446aade3da5034571 .centered-text-area { min-height: 80px; position: relative; } .ud6d64ed4f6c7d79446aade3da5034571 , .ud6d64ed4f6c7d79446aade3da5034571:hover , .ud6d64ed4f6c7d79446aade3da5034571:visited , .ud6d64ed4f6c7d79446aade3da5034571:active { border:0!important; } .ud6d64ed4f6c7d79446aade3da5034571 .clearfix:after { content: ""; display: table; clear: both; } .ud6d64ed4f6c7d79446aade3da5034571 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .ud6d64ed4f6c7d79446aade3da5034571:active , .ud6d64ed4f6c7d79446aade3da5034571:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .ud6d64ed4f6c7d79446aade3da5034571 .centered-text-area { width: 100%; position: relative ; } .ud6d64ed4f6c7d79446aade3da5034571 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .ud6d64ed4f6c7d79446aade3da5034571 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .ud6d64ed4f6c7d79446aade3da5034571 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .ud6d64ed4f6c7d79446aade3da5034571:hover .ctaButton { background-color: #34495E!important; } .ud6d64ed4f6c7d79446aade3da5034571 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .ud6d64ed4f6c7d79446aade3da5034571 .ud6d64ed4f6c7d79446aade3da5034571-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .ud6d64ed4f6c7d79446aade3da5034571:after { content: ""; display: block; clear: both; } READ: The play An Inspector Calls Essay SummaryIII.I.ll 154-161. During the play performed by the Players, Hamlet speaks to Ophelia with heavy sexual connotations behind his words. Do you think I meant country matters? III.ii.l 115. Thats a fair thought to lie between maids legs III.ii.l 117. Ophelia is a noblewoman and yet, she is subject to embarrassing conversations that a servant woman would normally endure. This is saying that all women are alike and they have no class distinctions between them as men do. Even when Hamlet speaks with Gertrude in her room, he makes many references to her incestuous bed. Nay, but to live/ In the rank sweat of an enseamed bed, / Stewed in corruption, honeying and making love/ Over the nasty sty! III.iv.ll 102-105. Women are subject to whatever faults men place on them instead of themselves. Within the play Hamlet, the role of women is very negative; they are sexual objects, weak, and not independent. Shakespeare has used a model of the women of his time and put them into this play, Hamlet. Though time has passed and views have changed on women, Hamlet remains the same, stuck in the 17th century. The role of women in Hamlet remains very minimal and only serves to further enhance and characterize the male characters within the play.

Sunday, March 8, 2020

Molecular Mechanisms, Symptoms and Treatments in Cystic Fibrosis The WritePass Journal

Molecular Mechanisms, Symptoms and Treatments in Cystic Fibrosis Introduction Molecular Mechanisms, Symptoms and Treatments in Cystic Fibrosis IntroductionMolecular MechanismsSymptomsCurrent TreatmentsFuture TreatmentsConclusionRelated Introduction Cystic fibrosis is a genetic disorder currently affecting over 9000 people living in the United Kingdom alone, with millions of people carrying the faulty recessive gene responsible for the disease. This essay is split into 4 distinct sections, firstly looking at the faulty gene and its effects on the organs of the body, followed by an in-depth look at the symptoms of patients suffering with cystic fibrosis, whereas the third section will look at the treatments available to sufferers. The forth section will contain potential future cures and treatments for the cystic fibrosis. Molecular Mechanisms The faulty gene that codes for cystic fibrosis affects organs such as the lungs and pancreas. This fault causes high mucosal build up in these organs. Noticeably with regards to the lungs as the high volume of mucous can cause severe breathing difficulties. The cystic fibrosis transmembrane regulator (CFTR) protein is coded for by the CFTR gene, in chromosome 7 of the human genome. CFTR is a glycoprotein made up of 1480 amino acids consisting of 5 domains. The CFTR protein is responsible for a variety of functions in the apical membranes of cells including the transport of chloride ions, regulation of the sodium ion channels and the regulation of hydrogen carbonate ion transport across the apical membrane[3]. However, it seems that the main contributing factor to cystic fibrosis is the transportation of chloride ions across the apical membrane and sodium ion regulation. Mutations in the CFTR gene can be categorized into 6 classes; depending on the effect they have on the production of the CFTR protein. The mutations are listed below in Figure 1, with the consequence of the mutation on the CFTR protein. Mutation Number Consequence of Mutation I Not synthesised II Inadequately processed III Not regulated IV Shows abnormal conductance V Partially defective production VI Accelerated degradation Figure 1 – Table showing the Mutation Number and the Consequence of the mutation on the CFTR protein The mutations stated in figure 1, either cause the CFTR protein to become ineffective or prevents synthesis altogether. Classes I and III prevent synthesis of the CFTR protein, whereas other mutations cause problems in the production of the protein.   Class II mutations effects can vary from the CFTR protein being completely dysfunctional to significantly reduced function depending on the patient. Class IV and Class V mutations do not cause the CFTR protein to cease working, but do have a derogatory effect on their function. Class VI mutations cause before-time degradation of the protein meaning reduced function. One of the consequences of the CFTR protein not functioning in cystic fibrosis patients is a high concentration of chloride ions developing in the intracellular space, as well as little regulation of sodium ions entering the cell. Under normal circumstances water would diffuse out the cell and contribute to the airway surface liquid as the concentrations of chloride and sodium ions would be higher in the extracellular space. However with a defective CFTR gene the osmotic gradient is reversed. Thus leading to a high ion concentration within the cell and depletion in the airway surface liquid. Cilia are small hair like projections in the respiratory tract which are responsible for wafting the mucous up the respiratory tract so it can be swallowed and infection averted. Mucous is one of the body’s primary physical defences against bacterial infection. Pathogens capable of causing respiratory disease are caught on the mucous in the respiratory tract and eventually swallowed with the aid of cilia thus avoiding the entry of pathogens into the lungs and causing bacterial infection.   Airway surface liquid also prevents infection by facilitating the movement of mucous up the respiratory tract. However when there is depletion in airway surface liquid, the cilia are also affected. The mucous therefore needs to be of low viscosity so it can be easily moved up the respiratory tract. However, due to the lack of airway surface liquid in a patient with cystic fibrosis the mucous becomes static and more viscous leading to bacterial infections in the lungs. Cystic Fibrosis does not just affect the lungs in some cases. Occasionally, the pancreas and in the case of men, reproductive organs can be affected. This all depends on which class of mutation of the CFTR gene the patient has as patients with Class I, II and III are prone to pancreatic insufficiency3. In normal pancreatic exocrine secretion, the digestive enzymes secreted from pancreatic gland cells, are mixed with a bicarbonate-rich fluid, secreted from duct cells and released into the small intestine to aid in the digestion of food. The function of the pancreatic gland cells remains fairly constant, but there is a noticeable difference in secretion of the bicarbonate-rich fluid from the duct cells. Thickening secretions causes the duct releasing fluids into the small intestine becomes blocked by enzymes precipitating as well as mucosal build up. With the ducts becoming more blocked, the pressure inside the pancreas increases and as the pancreas lacks structures aiding in support i s therefore very prone to damage. Symptoms Cystic fibrosis effects different organs around the body and therefore gives rise to a vast range of symptoms. The organs most heavily affected by cystic fibrosis are the lungs and the pancreas, and in males, the reproductive organs are affected. The most obvious indication that a patient may have cystic fibrosis would be a family history of the disease. As cystic fibrosis is a genetic disorder, the faulty recessive gene can be passed to children. Due to the gene being recessive, it is possible for parents to be a carrier for cystic fibrosis but not express any symptoms themselves. Therefore if both parents are carriers of the gene, then there is a 25% chance of the offspring having cystic fibrosis.   From 2009 onwards it is required for new-born babies in the USA to be screened for genetic disorders like cystic fibrosis. If positive, it gives doctors an opportunity to act quickly and maybe prevent other more serious problems, related to cystic fibrosis developing later in life[7]. Other common symptoms that are shown by most ages are salty tasty skin, clubbing of the fingers and toes, coughing with sputum production, mucoid Pseudomonas aeruginosa isolated from airway secretions and hypochloraemic metabolic alkalosis[8]. The symptoms shown by the patient are also different depending on their age. Figure 2 shows a table listing the symptoms by age they become prevalent. Neonatal Infancy Childhood Adolescence and Adulthood   Meconium ileus Persistent infiltrates on  chest  radiographs Chronic pansinusitis or nasal polyposis Allergic bronchopulmonary aspergillosis Protracted jaundice Failure to thrive Steatorrhoea Chronic pansinusitis or nasal polyposis Abdominal or scrotal calcifications Anasarca or hypoproteinaemia Rectal prolapse Bronchiectasis Intestinal atresia Chronic diarrhoea Distal intestinal obstruction syndrome  or intussusception Haemoptysis Abdominal distention Idiopathic recurrent or chronic pancreatitis Idiopathic  recurrent pancreatitis Cholestasis Liver disease Portal hypertension Staphylococcus aureus  pneumonia Delayed puberty Idiopathic intracranial hypertension (vitamin A deficiency) Azoospermia  secondary to congenital bilateral absence of the  vas deferens Haemolytic  anaemia Figure 2 – Depending on the age of the patient, different symptoms for Cystic Fibrosis will be apparent shown in the table above8 As shown in Figure 2, cystic fibrosis has a big effect on many parts of the body. However, the main problem for a patient with cystic fibrosis remains pulmonary disease and the effect of the gastrointestinal problems which arise. Innate defence mechanisms like the physical barrier provided by the mucous, lining the respiratory tract, is inefficient at its function in a patient with cystic fibrosis. This therefore leads high levels of bacterial infection and inflammation. The bacterial infections begin soon after birth with Staphylococcus aureus and Haemophilus inï ¬â€šuenzae usually being the pioneer bacteria causing primary infection in the lungs of a patient. It has been suggested that these bacteria are responsible for damaging the epithelial surface cells and therefore aiding other bacteria bind to the surface, however this is still under debate by scientists. However, Pseudomonas aeruginosa is the organism responsible for the later, fatal infections that cause the highest mortality rate in patients with cystic fibrosis. The CFTR protein not only has functions transporting ions, but it is also thought to have a role in binding molecules of Pseudomonas aeruginosa. In a normal individual, Pseudomonas aeruginosa binds to the CFTR protein, and a rapid and self-limiting inï ¬â€šammatory response9 occurs removing the infection from the respiratory tract. This explains why Pseudomonas aeruginosa is the main causative agent of pulmonary disease in cyst ic fibrosis sufferers. Symptoms of cystic fibrosis caused by gastrointestinal problems are mainly caused by the inability to digest food. As mentioned above the ducts leading to the small intestine, which would carry a liquid, containing digestive enzymes is blocked. This causes the pancreas to come pressure and gets damaged. The symptoms caused by this inability to digest food are greasy stools,  flatulence, abdominal bloating, and poor  weight gain8. At the time of its discovery, malnutrition was the main cause of death due to the inability to produce the enzymes in the pancreas to digest food. Malnutrition can now be treated using pancreatic enzyme replacement therapy8, however other factors like the poor adsorption of fat soluble vitamins can lead to acrodermatitis, anaemia, night blindess, neuropathy, osteoporosis and bleeding disorders8. A high percentage of Cystic fibrosis patients can develop Cystic Fibrosis related Diabetes Mellitus (CFRD) due to the pancreatic damage that is done by the blocking of the ducts within in the pancreas. The Islet of Langerhans produces insulin and glucagon to regulate blood glucose concentrations. Insulin stimulates the formation of glycogen, removing glucose from the blood stream whereas glucagon stimulates the breakdown of glycogen. With the pancreas undergoing autolysis, it is inevitable that these cells will become damaged and unable to produce a sufficient amount of insulin. However, CFRD is different to diabetes mellitus I and II. The specific symptoms affected by cystic fibrosis are glucose metabolism,   acute and chronic infection, glucagon deficiency, liver dysfunction, decreased intestinal transit time, and increased work of breathing8. Cystic fibrosis also affects male reproduction. In the male reproduction organs, the vas deferens is responsible for the transfer of sperm from the epididymis in anticipation of ejaculation8. Male patients with cystic fibrosis lack this muscular tube and therefore there is no sperm in their ejaculate. Women however are fertile, but careful control of nutritional intake must be taken to ensure the full term of pregnancy and subsequent birth can be achieved. I can be possible for parents to pass the gene for cystic fibrosis onto their children. As a man expressing the disease being infertile the recessive gene must come from a carrier of cystic fibrosis but not expressing any symptoms. If the female sufferers from cystic fibrosis then there is a 50% chance that the child will also have the disease. However if the female is also a carrier of the recessive gene then there is a 25% chance that the child will have cystic fibrosis. Current Treatments As it stands at the moment, cystic fibrosis cannot be cured. Cystic fibrosis is a genetic disease, and therefore there is an error in the DNA of cells of an individual apart from their gametes. This means that the only available option to sufferers is to find drugs to treat the various symptoms. However in recent years there have been successful attempts to find drugs to resolve the original defects. Patients with cystic fibrosis often suffer from severe pulmonary infections, as they are less efficient at swallowing mucous containing pathogens. The airway surface liquid and cilia, as discussed above are responsible for the movement of mucous up the respiratory tract in a normal individual. Cystic fibrosis sufferers lack the required volume of airway surface liquid. One such treatment, looking to solve the problem caused by the faulty gene is hypertonic saline. Hypertonic saline is the current drug used to bring about an increase in the volume of airway surface liquid in the lungs of the patients. It has been shown by researchers that in vitro, hypertonic saline is effective with rehydrating and providing more airway surface liquid8. If from an early age there is aid with mucosal clearance from the respiratory tract, it would reduce the chances of the patient developing severe bacterial infections from pathogens such as pseudomonas aeruginosa. Antibiotics are also important to control pulmonary bacterial infections that occur from poor mucosal clearance. Macrolide antibiotics are cheap antibiotics used to treat cystic fibrosis sufferers. They work by inhibiting the bacteria protein biosynthesis; however the precise mechanism they use is currently not fully understood. Macrolides have a dual function in the cystic fibrosis treatment. They affect cytokine production of many cell types and are therefore effective as anti-inflammatory agents8. One study showed that taking azithromycin three times a week reduced the virulence factor production, decreased biofilm production, bactericidal effects on pseudomonas aeruginosa growing in stationary phase8. Patients with gastrointestinal symptoms brought about by cystic fibrosis require other forms of treatment, as they unable to produce enough enzymes to digest their food. Enzymes are usually secreted from the pancreas into the small intestine, allowing the individual to digest their food. However a patient with pancreatic insufficiency is unable to secrete the enzymes into the small intestine due to the intrapancreatic ducts being blocked. This needs to be treated as patients are at risk of severe malnutrition if food cannot be fully digested. Pancreatic Enzyme Replacement Theory (PERT) is used to treat this problem. The enzymes used in PERT are taken with every meal to aid in the absorption of food in the small intestine.   This does not solve the underlying problem caused by cystic fibrosis, and can only treat the symptoms. This is because the enzymes do not last for a great deal of time in the body; the reason why enzymes must be taken with every meal. Chest physiotherapy can aid in the treatment of a sufferer as it can help in mucosal clearance from the pulmonary tract[11]. Some methods focus on the way the patient breathes which include active cycle of breathing techniques, and autogenic drainage11. However some techniques focus on actual mucosal clearance like positive expiratory pressure (PEP) oscillating positive expiratory pressure11. The final and most severe treatment used to use the chronic pulmonary disease is lung transplantation. This procedure comes with high risk with only 50% children surviving 5 years after the transplant and 50% of adults surviving 6 years after the transplant8. Future Treatments As of yet there is no cure for cystic fibrosis, however there are promising new drugs on the horizon which could one day all but cure the genetic disease. A drug that is combatting the â€Å"basic defect† of cystic fibrosis is VX-770 made by Vertex pharmaceuticals. This drug is currently undergoing trials in the United States of America and is showing promise for improving lung function in those affected by cystic fibrosis. The drug itself targets the chlorine channels in the apical membrane, opening them to allow chlorine to leave the epithelial cells. Results from the recent Phase 3 clinical trials showed that there was a 10% increase in lung function in people aged 12 and above, and a 12.5% increase in lung function for those from ages 6 to 11. The drug also decreased the concentration of chlorine in sweat and allowed the patients taking the drug to gain on average 7 pounds12. Pancreatic insufficiency usually makes it hard for the cystic fibrosis patient to gain weight, meaning the drug has an effect on gastrointestinal symptoms as well as respiratory symptoms. The idea of gene therapy is a concept that has been around for a while. The Cystic fibrosis gene therapy consortium was set up in 2001 to focus on developing new ways to combat cystic fibrosis and the symptoms. In February 2009, the consortium made a step closer to find a â€Å"gene therapy cure† for cystic fibrosis. They managed to insert successfully, a working CFTR gene into a viral vector, which was then transported into the lungs of a cystic fibrosis patient. Whereas the idea itself is good, there are some drawbacks. The viral vector itself comes under attack from the immune system as well as viral vectors being poor at inserting DNA into epithelial cells8. Therefore the The Cystic fibrosis gene therapy consortium has been looking at using lipid vectors currently with little success. They have reported that currently gene expression in the cells that do take up the gene is currently temporary and they are looking into methods to provide sustained gene expression in the ep ithelial cells. Not all mutations cause the CFTR protein not to be synthesised. Some mutations cause the CFTR protein to be marked for degradation as the chaperones, aiding with folding the protein, do not dissociate from the protein8. There have been tests in labs using chemicals such as phenylbutyrate8, however any further developments in this field of research. Conclusion It is remarkable how such a small difference in the DNA of an individual can have so much effect on the patients’ health.   However the future looks bright for those patients suffering with cystic fibrosis. There is a huge amount of research taking place in order to find new treatments and potential cures for the disease. Recently, research has shifted from looking for ways to treat the symptoms, to methods of treating the underlying problems behind the disease. For example a drug called VX-770 made by Vertex Pharmaceuticals, focuses on the inefficient chlorine channels in the epithelial cells. If cystic fibrosis remains a continually financially backed area of research, there is no reason why significant progress cannot be made sooner rather than later.

Friday, February 21, 2020

Ethics and the Indian Laborer Essay Example | Topics and Well Written Essays - 1000 words

Ethics and the Indian Laborer - Essay Example Therefore, Indian government and manufacturing supervision are putting profits ahead of the Indian health condition with no additional compensation for these poor working conditions for the laborer. Even though international agencies such as the United Nations continue to exert pressure on improving labor reform, such groups have little to no legal influence in these countries and no changes are implemented for the Indian employee. Â  Another difficulty in providing ethical behavior for the workers is the tiered system of production common for clothing manufacture in India. Many American companies source their apparel brands with a large textile company where orders are placed and final shipment of the merchandise is delivered. However, these companies have tiers of manufacture that include small factories and individual workers that do hand-beading, sequin work, embroidery and other associated decoration on more expensive clothing (Level Works Limited, 2009). Those smaller companie s’ low-skilled laborers that are not protected under the jurisdiction of certain labor laws are usually managed by independent business owners. The companies from the U.S. that source in this way are aware of these tiers of supply, but do little to invest capital into building a more efficient supply network in the larger company. In this case, the American manager is turning away from the plight of the exploited second and third tier employees in the process while India allows private companies to keep quality laborers in the poverty zone.

Wednesday, February 5, 2020

Quantitative Article Review Example | Topics and Well Written Essays - 500 words

Quantitative Review - Article Example One child from the household was randomly selected. Adolescents fulfilling the diagnostic criteria as well as having number of symptoms one or more standard deviation above mean were entitled to be having a psychiatric disorder. Proportional risks of unfavorable adolescent outcomes and confidence intervals at 95% were calculated for every depressive diagnosis, psychiatric diagnosis, anxiety diagnosis, substance abuse diagnosis and disruptive diagnosis. The outcomes revealed that the adolescents with anxiety, depressive, disruptive and substance abuse disorder were found to be 2.86-2.91 times more likely to experience failure in completing secondary school education as compared with young adults without psychiatric disorders. Young adults with disruptive disorders were found to be 4.04 (1.96–8.32) times more probably to get in difficulty with police during early adulthood as compared to those without disruptive disorders. The positive prognostic value of every psychiatric disorder measure for not completing school was greater in the lowest SES stratum and for adolescents criminal involvement was greater for boys. The combination of age, gender, symptom counts and social class within a logistical regression model conceded 87% specificity and 89% sensitivity at p≠¥0.13 cut off for forecasting succeeding school non-completion. Future criminal involvement on the other hand when tested at the optimum cutoff value yielded 76% specificity and 75% sensitivity (Vander et al., 2002). Going through the given study a novel technique of utilizing various symptoms of psychiatric disorders for predicting not completing school education and the involvement of adolescents in criminal behavior was analyzed. The overall model used was significant and required professional skills to handle as the sample was quite large. However since the study involved two areas of similar geography, it can be expanded to geographical units

Monday, January 27, 2020

Business Strategy And Planning Of Costcutter

Business Strategy And Planning Of Costcutter The corner shop or convenience store, as it is sometimes labelled, has been a feature of retail life in cities and towns from Roman times, if not earlier. To be sure, the Romans articulated the role of the convenience store in everyday life, developed its corporate identity and regarded it as an enterprise that operates optimally within the range of footfall. The Roman streetscape was littered with these stores, most engaging prominent positions, some even corner positions, but all dominating the facades of the masonry buildings they occupied. A characteristic of the Roman convenience store was its integration into the local market, sourcing locally grown farm produce, supplying locally refined products and distributing this merchandise at a local level. With the passage of time, the convenience store began to infiltrate the New World, and remained a characteristic feature of retail life in countries such as Australia, Canada and the United States, until well after the Second World War. But from the 1960s, as the economies of the industrialised world entered a rapid phase of expansion, the supermarkets emerged as the dominant players in the retail grocery sector. Yet, the convenience store managed to survive as a viable economic entity. Nowadays, even supermarket giants such as Tesco and Sainsburys here in the United Kingdom, have begun to penetrate the lower echelons of the retail grocery sector with their own version of the corner shop. Using this concept as a launch pad, Tesco has already made inroads in the United States, though with varying degrees of success. Moreover, Tesco harbours further ambitions to establish its convenience scale outlets in such emerging economies as South Korea. On the face of it, very little appears to have changed over the millennia since the Romans devised the concept of the convenience store. Neighbourhood stores, if they form part of a larger national chain, are still obsessed with such issues as corporate image and identity, not to mention their strategic role in the local market.1 What has changed, however, is the largely oligopolistic nature of the retail grocery sector. By 2010, the major participants in this sector Tesco, Sainsburys, Asda and Morrisons controlled 65.4 per cent of a grocery market valued by industry analysts at a staggering  £118.2 billion2. Given the strongly oligopolistic character of this market, it is hardly surprising to observe that these key players have developed planning strategies that virtually anticipate their competitors next move. In other words, their behaviour is very much retaliatory! There is evidence, too, to suggest that this behaviour is being emulated in the convenience store segment of the market, where the hallmarks of oligopolistic competition are just starting to appear3. COSTCUTTER Costcutter is one of the United Kingdoms leading convenience store chains. Although the majority of the stores trading under its banner are based here, Costcutter also operates outlets in Northern Ireland and Poland. As a typical grocery retailer, Costcutter stocks a comprehensive range of groceries, alcoholic products, tobacco and confectionery. However, Costcutter operates two distinct retail store models : (a) the directly owned outlet; and (b) the independently owned franchised outlet. Both models benefit from economies of scale, so that as the organization grows, so too, does its purchasing power. Yet, those outlets that are independently owned tend to operate along the lines of a retailers cooperative. Costcutter has developed a high profile corporate image, which is bolstered by its own range of branded products. Groceries bearing the company brand name are often shelved alongside those of Nisa Today Costcutters warehousing and distribution affiliate. The companys headquarters are based in Yorkshire. As of December 2006, ownership of Costcutter is vested in James A Barry Co.4 COMPANY HISTORY Costcutter was founded in 1986 by Colin Graves, a former sales employee of the SPAR grocery group. In the short space of just 12 months, Graves set up seven stores in Yorkshire. By 1991, Costcutter had opened its first outlets in Scotland and Northern Ireland. In 1992, the company established a grocery distribution centre in Barnsley. It was then keen to develop its corporate image and identity. By the mid-1990s, Costcutter operated some 500 outlets throughout the United Kingdom, the majority of them franchise-owned. In 2004, Costcutter merged 50 of its outlets with the MURCO fuel distribution group. Thereafter, the Costcutter convenience store found its way onto the forecourts of an increasing number of MURCO petrol filling stations. In addition to their grocery lines, these stores stock car care products and accessories. Exponential growth followed. By 2007, largely driven by a successful franchise recruitment campaign, the total number of outlets under its corporate banner, grew to 1500. Sales turnover exceeded  £600m in 2010, making the company one of the most significant players in the grocery retail sector. For all that, Costcutter is not unlike the other key players in the convenience store market. Costcutter stores occupy prominent high street positions with a typical catchment area covering a radius of a quarter mile. The company continues to enjoy solid growth, though recently its development strategy increasingly promotes direct ownership of outlets. At present, more than 1200 stores in the chain are independently owned by franchisees.5 Business models, concepts and tools in business strategy and planning of costcutter At an early stage in its corporate history, Costcutter put growth at the centre of its retail development strategy. Indeed, the company conducts an aggressive retail recruitment drive to enlist new franchise owners. Ideally, the company seeks existing operations which engage high footfall volumes and occupy floor space of between 1,000 to 1,500 square feet. By contrast, the typical Sainsburys Local or Tesco Express occupies a floor space of between 2,000 to 6,000 square feet. Costcutter does not regard the absence of car parking as an issue. There are a number of advantages which Costcutter offers its franchise owners: an association with a well-established high profile retailer continuous retail training and technical support generous profit margins a loyalty scheme which rewards franchise owners for centralised purchasing improved credit terms both within the group and externally the cost benefits of group purchasing power fast and cost-effective Epos accounting and inventory control an efficient and reliable supply chain cycle a robust business development strategy deploying the services of a range manager to maximise profits and sales turnover extensive national, local and in store advertising6 As an adjunct to this, each franchised outlet is indelibly stamped with the Costcutter corporate identity. All newly franchised premises are refurbished to the Costcutter specification, though refits are tailored to a range of budgets. The process of nurturing company image is achieved through: a conspicuous company logo which largely resembles a banner distinctive company fascia advertising the use of a thematic colour palette to harmonise the in-store ambience the use of a standardised in-store lighting format in-store radio providing a continuous voice for product promotion the shelving of Costcutter branded products extensive advertising The cost of a Costcutter franchise is between  £70,000 to  £100,000. Annual management fees amount to  £1880. Projected first year net profit for a typical outlet is in the region of  £100,000.7 THE BUSINESS DEVELOPMENT STRATEGY At the heart of Costcutters retail development strategy is growth itself. It improves market share and even allows new products to be sold. Above all, growth promotes economies of scale. Such economies are reflected in the companys burgeoning purchasing power and presence in the wholesale distribution markets. From its inception, Costcutter has enjoyed continuous year-on-year growth, despite predatory competition from the huge multiples. Growth has been achieved through: the setting of annual expansion targets a vigorous franchise recruitment program, as noted above the defection of other franchisees from the ranks of competitors notably, from the SPAR group the direct acquisition of small groceries the purchase of other outlets under administration8 Continuous expansion of the Costcutter chain remains a development priority. Not surprisingly, Costcutter has devised an ambitious overseas expansion drive, which at present has targeted such emerging powerhouse economies as India and Pakistan. But such proposed international development is to be accompanied by further consolidation of its core business in the United Kingdom.9 In recent years, Costcutter established a close relationship with Nisa Today, the leading independent wholesale distributor of groceries throughout the UK. Critical to the companys development is the vertical integration of wholesale grocery distribution. Costcutters affiliation with Nisa Today partly achieves this objective. But in 2007, the Bibby Line group, a direct competitor to Nisa Today, acquired a 51% shareholding in Costcutter. In the event, Nisa Today has retaliated by establishing its own retail outlets.10 Despite this, the growth strategy of Costcutter remains the same. That approach incorporates a number of other marketing facets: the development of new lines, especially fresh, locally sourced products promotion of the concept of value for money a narrowing of the cost profile between its outlets and those of the huge multiples promotion of the concept that Costcutter can deliver quality food as needed, thereby avoiding the arduous weekly shopping event an increasing investment in technology, especially as its relates to online marketing the promulgation of a company ethos, culture and set of values, as noted below11 Appraise processes of Costcutter to identify their goals and values THE COSTCUTTER ETHOS Not unlike Tesco, Costcutter espouses a human relations approach that values its customers and staff. The company prides itself in the marketing of fresh, quality products. But unlike Tesco employees and management, Costcutters staff are versatile individuals, well versed in product knowledge across its full range. In addition, all staff together with franchise owners, benefit from continuous retail training. All franchise owners undergo a rigorous induction course. Furthermore, the company has established its own academy to equip store managers and their staff with cutting edge retail techniques. The development of customer loyalty through harmonious relations and rapport is central to the company ethos.12 ANALYSIS OF THE COSTCUTTER GROUP Central to the development strategy of the Costcutter group is its continuing growth. Using the convenience store model it has developed for the UK market, Costcutter is poised to make significant inroads into the emerging markets of Asia. But it is here in the United Kingdom, that Costcutter has reached a mature stage in its evolution. At the top end of the grocery retail sector, leviathans such as Tesco and Asda compete for market share, in what is overwhelmingly an oligopolistic market. Retaliatory marketing techniques are a conspicuous feature of such markets, as these companies clearly demonstrate. Yet, as companies like Costcutter continue to expand, even the bottom end of the retail grocery sector is beginning to display oligopolistic behaviour. Second guessing the competitors next move is par for the course. Nevertheless, Costcutter seems well positioned to fare better than most of its competitors, as it signs up an increasing number of franchisees, attracted by its generous profit margins and reduced overheads. 4.0 CONCLUSION The convenience store has endured as a potent force in the retail grocery sector, despite increasing competition from the huge multiples, such as Tesco and Sainsburys. Indeed, the blue print for the convenience store has largely remained the same since the Romans articulated its role in everyday life. Costcutter remains a robust example of the convenience store concept. The floor space of the typical Costcutter outlet is less than one quarter that of its major rivals notably, Sainsburys Local and Tesco Express. In this way, the typical Costcutter outlet manages to reduce its overhead costs, and at the same time, benefit from the substantial purchasing power of the Costcutter group itself. As a convenience store chain, Costcutter lacks the bureaucratic structure of the huge multiples. Instead, it fosters a more flexible and independent approach to its management. Such flexibility enables its local outlets to purchase outside the central distribution arm of the organization. In recent times, this has allowed the company to stock more local fresh produce. Thus, Costcutter can be perceived as a highly evolved and adaptable form of enterprise, and one which is not just sensitive to the tastes and preferences of the local market, but in some instances, equally sensitive to its ethnic composition.

Sunday, January 19, 2020

A Marxist Reading of One Flew over the Cuckoo’s Nest Essay -- One Flew

Fred Wright, Lauren's instructor for EN 132 (Life, Language, Literature), comments, "English 132 is an introduction to English studies, in which students learn about various areas in the discipline from linguistics to the study of popular culture. For the literature and literary criticism section of the course, students read a canonical work of literature and what scholars have said about the work over the years. This year, students read One Flew over the Cuckoo's Nest, by Ken Kesey, a classic of American literature which dates from the 1960s counterculture. Popularized in a film version starring Jack Nicholson, which the class also watched in order to discuss film studies and adaptation, the novel became notable for its sympathetic portrayal of the mentally ill. For an essay about the novel, students were asked to choose a critical approach (such as feminist, formalist, psychological, and so forth) and interpret the novel using that approach, while also considering how their interpr etation fit into the ongoing scholarly dialogue about the work. Lauren chose the challenge of applying a Marxist approach to One Flew over the Cuckoo's Nest. Not only did she learn about critical approaches and how to apply one to a text, she wrote an excellent essay, which will help other readers understand the text better. In fact, if John Clark Pratt or another editor ever want to update the 1996 Viking Critical Library edition of the novel, then he or she might want to include Lauren's essay in the next edition!" At first glance, a reader may wonder how Ken Kesey’s novel One Flew over the Cuckoo’s Nest, a book depicting a group of mentally unstable men and their boisterous Irish-American leader, connects with the economic and sociological view o... ...lett, Moyra. Marxist Literary and Cultural Theories. New York: St. Martin’s Press, 2000. Print. â€Å"Industrial Revolution.† The New American Desk Encyclopedia. 5th ed. 1989. Print. Kappel, Lawrence. Readings on One Flew over the Cuckoo’s Nest. San Diego: Greenhaven Press, 2000. Print. Kesey, Ken. One Flew over the Cuckoo's Nest. Ed. John Clark Pratt. New York: Viking-Penguin, 1996. Print. Viking Critical Library. Loeb, Roger C. â€Å"Machines, Mops, and Medicaments: Therapy in the Cuckoo’s Nest.† Lex et Scientia 13. 1-2 (1977): 38-41. Rpt. Kappel 85-91. Malin, Irving. â€Å"Ken Kesey: One Flew over the Cuckoo’s Nest.† Critique 5.2 (1962): 81-84. Rpt. in Kesey 440-444. â€Å"Marxism.† The New American Desk Encyclopedia. 5th ed. 1989. Print. Parker, Robert Dale. How to Interpret Literature: Critical Theory for Literary and Cultural Studies. New York: Oxford, 2011. Print.

Saturday, January 11, 2020

Financial Analysis of McDonalds Company

PART 1, COMPANY OVERVIEW:a. McDonald’s is an American fast food chain that sells a variety of fast food alternatives, but most notably has earned its reputation and success for the hamburger. It is the largest fast food chain in the world, with globally recognized â€Å"golden arches† symbolizing a reliable meal can be had in over 119 countries. McDonald’s has continued to develop their menu to reflect the desire/demands of their customers. The current CEO of McDonald’s is Mr. Don Thompson. b. McDonald’s was started in the 1940s as a BBQ restaurant owned and operated by Richard and Maurice McDonald’s in California, U.S.A.The McDonald’s franchise was not established until 1955, when man by the name of Ray Kroc opened the ninth McDonald’s restaurant in Des Plaines, Illinois. By 1961, McDonald’s filed trademark for the company name and â€Å"drive-thru† service. Ray Kroc eventually forced the McDonald’s brother s out of the business and successfully spread the company throughout the world. Today, McDonald’s is an international sign of globalization. c. McDonald’s invests in properties, operates restaurants, and is a franchiser of the McDonald’s chain, in order to make money. McDonald’s operates differently than most franchise companies. Most franchised companies make their money by claiming a percentage of the income made at each chain; however, often times McDonald’s Corporation will purchase the property the franchise is on and charge rent.d. Arguably, the main thing McDonald’s sells is uniformity and expectations. This is to say, when you order from McDonald’s you know what you will get every single time; no surprises. McDonald’s makes money doing this by selling the food for significantly more  than what they purchased it for. McDonald’s also makes money by participating in the strategy discussed above investing in proper ties and charging franchise owners rent, franchise markups of 40%, operating restaurants, etc. e. McDonald’s has over 33,000 locations in over 119 countries across the globe to include places like Israel, Brazil, Scotland, Russia, the U.S., India, and China. Within each of those countries McDonald’s can be found in a variety of places in a variety of forms; such as, coffee stands in Paris, drive-thru only restaurants in Germany, airport vendors, or even connected to gas stations.f. In recent years McDonald’s has taken criticism on the unhealthy food choices on their menu, so much to where at some restaurants they have listed the total caloric intake per meal. That said, McDonald’s was the official food sponsor of the 2012 Summer Olympics in London, England, where they built their largest restaurant to date to support the massive crowds.PART 2, FINANCIAL OVERVIEW:a. Sales and Income Record:————- Fiscal Years ——â₠¬â€Ã¢â‚¬â€-2007 2008 2009 2010 2011 Sales 22.79 23.52 22.74 24.07 27.01 Percent Change in Sales Each Year3% -3% 6% 12% Net Income 2.34 4.31 4.55 4.95 5.5 Percent Change in Net Income Each Year84% 6% 9% 11%GRAPH OF SALES & NET INCOME, FY 2007 ‑ 2011COMMENTS: Aside from 2009, the company has seen growth in both sales and net income every year. The decrease in sales for 2009 could possibly be a result of the economic times, where many of McDonald’s customers may have reduced their spending and become more conservative with their expenses. The growth percentages since 2010 are increasing, which indicates a positive trend in the company moving forward. It would be unrealistic to assume that the company can continue doubling its growth percentages, but a continued growth of 12% to 15% is possible.b. Expense Distribution:FY 2011 Major Expenses: COGS 16.3 SG&A 2.2 Interest 0.49 Taxes 2.5PIE CHART OF EXPENSES, FY 2011COMMENTS: As depicted in the chart, the companies’ largest expense is Cost of Goods Sold (COGS). In order to increase their profit margin, McDonald’s must continue to try and find ways to reduce COGS. This is because many of the other expenses are much harder to influence. Selling General and Administrative (SG&A) expenses have most likely already been trimmed to the minimum over the company’s life, taxes are required by the Government, and interest expense makes up only a small portion of expenses. The company may need to do a cost-benefit analysis to determine what may be done to reduce COGS. One idea may to better vertically integrate the company, or to remove menu items which are unpopular and/or seasonal.c. Assets Distribution:Year-end FY 2011 Assets: Cash 2.3 Accounts Receivable 1.3 Inventory 0.12 Fixed Assets (PP&E) 22.8 Other Assets 1.67PIE CHART OF ASSETS, Year-end FY 2011COMMENTS: As depicted in the chart, the companies’ assets are largely fixed. This comes as no surprise since the company consists of over 33,000 restaurant locations worldwide. The percentage of fixed assets as compared to current assets does mean though that the company is not liquid, which means it cannot quickly convert its assets to cash. The low inventory which actually makes up just 0.4% of the asset distribution is normal due to the fact that the company is a restaurant chain, and much of the product has a quick shelf life.c. Capital Structure: Year-end FY 2011 Capital Structure:Current Liabilities 3.5 Long-term & Other Liabilities 13.73 Common Equity 14.4CAPITAL STRUCTURE PIE CHART, Year-end FY 2011COMMENTS: As depicted in the chart, the companies’ capital structure is made up largely of common equity and long-term liabilities. The compa ny has been extremely successful, and has gained equity over the years as it became the world’s largest chain of hamburger fast food restaurants. Additionally, in order to continue their growth, the company has expanded its locations, which required long-term debt financing. Because of these characteristics,  the percentages of each of these categories are expected. Furthermore, the company has low current liabilities, which is normal for yearly operations in this sector.PART 3, RATIO ANALYSIS:(1) LIQUIDITY:Comments On McDonalds Liquidity:McDonald’s has a good current ratio. It is above 1, which means that it has enough current assets to cover current liabilities. Also, since the number is not too high, we know that the company is utilizing its assets efficiently. The quick ratio is also good because it is above 1, meaning McDonald’s does not rely on their inventory. Comparing the numbers to Wendy’s, McDonald’s has room for improvement.(2) ASSET MANAGEMENTComments On McDonalds Asset Management:McDonald’s has great Total Asset Turnover when compared with Wendy’s. They are making over $0.75 for every dollar of assets. Also, their Average Collection Period is very good, taking on average 18 days to collect on receivables.(3) DEBT MANAGEMENT:Comments On McDonalds Debt Management: Both companies’ debt ratios are similar, and are not alarming for the industry. However, McDonald’s Times Interest Earned is much higher than Wendy’s. This shows possibly lenders that McDonald’s can easily meet their interest owed (17x).(4) PROFITABILITY:Comments On McDonalds Profitability:For the industry, McDonalds has good profitability. Wendy’s seems to be struggling in this area, and it may be best to compare the company against another peer to determine how they are doing.(5) MARKET VALUE RATIOS:Comments On McDonalds Market Value Ratios:McDonald’s market value is good compared to both indust ry numbers, as well as against Wendy’s market value ratios. McDonald’s ratios prove the company is economically strong. Part 4, Summary and ConclusionThe McDonald’s Company is continuing to grow, both physically and monetarily, as seen in the increase in locations and sales per year. This is a good sign, especially during the current economic times. The company also has standard asset, expense, and capital distribution for companies within the fast food industry. This is good because there are no glaring issues that would inhibit investing in the company. Additionally, the company has great ratios when compared with The Wendy’s Company, as well as the rest of the fast food industry. One can fully understand how well the McDonald’s company is doing in comparison to the industry.Looking forward, the McDonald’s Company can try to get better by finding efficiencies where possible. One way the company could do this is by reducing its Cost of Good s Sold. Through eliminating some specialty items, this may be possible. Also, the company may want to look at a way to increase their return on assets and equity as any increase, large or small, will always help a company. Again, the company is doing extremely well already, but great companies should always continuously look for efficiencies and improvements in these areas.Overall, the McDonald’s Company has postured itself to become a large and extremely successful company within the fast food industry. It has grown from a small upstart in the 1940’s, to a symbol of globalization today  because of the multiplicity of restaurant locations around the world. I believe The McDonald’s Company is a great investment opportunity as it seems to continually improve, develop, and grow to serve its consumers around the world.

Friday, January 3, 2020

Social Limitations of Autism - Free Essay Example

Sample details Pages: 3 Words: 801 Downloads: 9 Date added: 2019/02/14 Category Medicine Essay Level High school Tags: Autism Essay Did you like this example? In a society that is deprived of face to face contact, it is very easy to get lost on your phone, tablets, etc. As members of society, we often task our social skills for granted, thinking that is automatic and something that everyone possesses, which isn’t the case. For people on the autism spectrum disorder, what people think is innate is what they struggle with the most. The issues that they face vary from person to person, but they all share the same ideal of isolation. Autism is classified as a disorder of neural development, which is often associated with restricted and repetitive behavior. It was first discovered by Leo Kanner in 1943, in which he believed that the disorder arose at birth and developed in the first few months of life. While many stigmatize autism and write it off as a mere case of mental retardation, there are many individuals that are affected by this label. The autism spectrum ranges from low functioning individuals who need 24/7 assistance to individuals who can fend for themselves but have a few social quirks. In fact, some people diagnosed with autism are listed savants, which are people diagnosed with Autism Spectrum Disorder that display extraordinary talents and surpass abilities of professionals that have studied a topic for years. With savants, their talent usually lies in something specific, an example being architecture. Without prior knowledge and one glance of a landscape, a savant could memorize the infra structure down to the last detail and draw it out perfectly. Even with this almost supernatural memory, a savant still has trouble socially, and most will just write him off as a â€Å"idiot savant†. Don’t waste time! Our writers will create an original "Social Limitations of Autism" essay for you Create order Social limitations in autistic individuals is a very complex and puzzling topic. The difficulties common for young children with ASD focus on their ability to engage jointly with others (joint attention/joint engagement), and the amount and quality of their interactive skills to enter into or maintain interactions with peers (Interventions Addressing Social Impairment in Autism, Kasan and Patterson). In a scientific context, the disorder correlates to impaired development of limbic connectivity, though in recent years it has become increasingly known that it affects all areas of the brain, as opposed to specific areas associated with social functioning. In terms of memory, a research study that included neurologist Nancy Minshew showed that children with autism lacked good memory for complex information in the form of words and pictures. In the same study, it also showed that they lacked working memory for spatial information, which meant recalling an item once it was no lon ger presented to them. Essentially, their memory is very fragile, and at times can find themselves repeating many things because they often don’t remember themselves saying it. To precisely pinpoint what may be going on in these children, various interventions have been developed in order to analyze a controlled environment of autistic patients. In a social skills intervention designed by Connie Kasari and Stephanie Patterson, the main targets were knowledge and conceptual understandings, peer relationships/friendships, and joint attention/joint engagement. The interventions were ran under the theory that sustained knowledge of social behavior would result in improving social interactions in real time. While focus on core deficits increased, future designs needed to address the active causes of interventions, which can be parents, environment, etc. Out of the 35 designed that required intervention, many were deemed weak, and only 3 were deemed strong. 2 of the studies considered strong were conducted by Kasari herself, and involved different types of intervention. The first one involved JASPER vs. delayed intervention involving 38 toddlers(n=38) and it measured observed joint engagement, play types, joint attention skills, and caregiver quality of involvement. The results yielded increases in immediate treatment gro up and decreased in object only engagement. The second study involved child assisted, peer assisted, and child plus peer vs. control intervention and it measured social network salience, playground observation, and teacher perception social skills. The results yielded child and peer group increases in social network salience over child, peer, and control while solitary engagement decreased for children in the peer intervention. The last strong study conducted composed of 61 preschool students(n=61). It involved joint attention intervention vs. treatment, and it measured observed duration of joint engagement. The results yielded increases in frequency of JA skills in teacher child interaction and increase in joint engagement, being the only study in the interventions that didn’t not see a decrease in anything. While the studies that were rated strong showed promise and serves as a template for future interventions, there is still a lot of work to be done to find something that can universally help out individuals affected by ASD. Not every autistic person turns out to be a savant, so a â€Å"Rain Man† approach cannot be applied to every person.